Detalhe da pesquisa
1.
Impact of ACE I gene insertion/deletion, A-240T polymorphisms and the renin-angiotensin-aldosterone system on COVID-19 disease.
Virol J
; 21(1): 15, 2024 Jan 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-38200555
2.
Transgenic mice overexpressing human ALOX15 under the control of the aP2 promoter are partly protected in the complete Freund's adjuvant-induced paw inflammation model.
Inflamm Res
; 72(8): 1649-1664, 2023 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-37498393
3.
Knock-in mice expressing a humanized arachidonic acid 15-lipoxygenase (Alox15) carry a partly dysfunctional erythropoietic system.
Cell Mol Biol Lett
; 28(1): 97, 2023 Nov 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-38030974
4.
Bony Fish Arachidonic Acid 15-Lipoxygenases Exhibit Different Catalytic Properties than Their Mammalian Orthologs, Suggesting Functional Enzyme Evolution during Vertebrate Development.
Int J Mol Sci
; 24(18)2023 Sep 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-37762455
5.
Functional Characterization of Transgenic Mice Overexpressing Human 15-Lipoxygenase-1 (ALOX15) under the Control of the aP2 Promoter.
Int J Mol Sci
; 24(5)2023 Mar 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-36902243
6.
Functional Characterization of Mouse and Human Arachidonic Acid Lipoxygenase 15B (ALOX15B) Orthologs and of Their Mutants Exhibiting Humanized and Murinized Reaction Specificities.
Int J Mol Sci
; 24(12)2023 Jun 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-37373195
7.
Humanization of the Reaction Specificity of Mouse Alox15b Inversely Modified the Susceptibility of Corresponding Knock-In Mice in Two Different Animal Inflammation Models.
Int J Mol Sci
; 24(13)2023 Jul 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-37446212
8.
Different Structures-Similar Effect: Do Substituted 5-(4-Methoxyphenyl)-1H-indoles and 5-(4-Methoxyphenyl)-1H-imidazoles Represent a Common Pharmacophore for Substrate Selective Inhibition of Linoleate Oxygenase Activity of ALOX15?
Molecules
; 28(14)2023 Jul 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-37513289
9.
Omega-3 fatty acids protect from colitis via an Alox15-derived eicosanoid.
FASEB J
; 35(4): e21491, 2021 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-33710695
10.
Functional Characterization of Novel Bony Fish Lipoxygenase Isoforms and Their Possible Involvement in Inflammation.
Int J Mol Sci
; 23(24)2022 Dec 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-36555666
11.
Unbalanced Expression of Glutathione Peroxidase 4 and Arachidonate 15-Lipoxygenase Affects Acrosome Reaction and In Vitro Fertilization.
Int J Mol Sci
; 23(17)2022 Aug 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-36077303
12.
Dichloroacetate and PX-478 exhibit strong synergistic effects in a various number of cancer cell lines.
BMC Cancer
; 21(1): 481, 2021 Apr 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-33931028
13.
Systemic deficiency of mouse arachidonate 15-lipoxygenase induces defective erythropoiesis and transgenic expression of the human enzyme rescues this phenotype.
FASEB J
; 34(11): 14318-14335, 2020 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-32918502
14.
Expression Silencing of Glutathione Peroxidase 4 in Mouse Erythroleukemia Cells Delays In Vitro Erythropoiesis.
Int J Mol Sci
; 22(15)2021 Jul 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-34360557
15.
Conformational Heterogeneity and Cooperative Effects of Mammalian ALOX15.
Int J Mol Sci
; 22(6)2021 Mar 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-33807076
16.
High amplitude stretching of ATII cells and fibroblasts results in profibrotic effects.
Exp Lung Res
; 45(7): 167-174, 2019 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-31290711
17.
Evolutionary alteration of ALOX15 specificity optimizes the biosynthesis of antiinflammatory and proresolving lipoxins.
Proc Natl Acad Sci U S A
; 113(30): E4266-75, 2016 07 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-27412860
18.
Atopic Patients Show Increased Interleukin 4 Plasma Levels but the Degree of Elevation Is Not Sufficient to Upregulate Interleukin-4-Sensitive Genes.
Skin Pharmacol Physiol
; 32(4): 192-200, 2019.
Artigo
em Inglês
| MEDLINE | ID: mdl-31096247
19.
Specific oxygenation of plasma membrane phospholipids by Pseudomonas aeruginosa lipoxygenase induces structural and functional alterations in mammalian cells.
Biochim Biophys Acta Mol Cell Biol Lipids
; 1863(2): 152-164, 2018 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-29146531
20.
Crystal structure and functional characterization of selenocysteine-containing glutathione peroxidase 4 suggests an alternative mechanism of peroxide reduction.
Biochim Biophys Acta Mol Cell Biol Lipids
; 1863(9): 1095-1107, 2018 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-29883798